Basic information of α-Cyclodextrin
- Product Name: α-Cyclodextrin
- English Aliases: α-CD, Cyclohexapentylose, Cyclomaltohexaose, Alfadex, Schardinger α-dextrin
- Industry Abbreviation: α-CD
- CAS No.: 10016-20-3
- Molecular Formula: C₃₆H₆₀O₃₀
- Molecular Weight: 972.84 g/mol
- Applications: Pharmaceuticals, food, cosmetics, animal feed, etc.
- Quality Standards: Complies with USP, EP, FCC, GB, and other standards
- Detection Methods: HPLC, UV, IR, optical rotation determination
- Delivery Time: Samples: 3-5 working days; Batch: 7-15 working days
- Packaging Specifications: 1kg/aluminum foil bag, 25kg/cardboard drum, customizable
- Quality Assurance: Full inspection before leaving the factory to ensure product quality meets standards
Physicochemical Properties of α-Cyclodextrin
- Appearance and Odor: White to off-white crystalline powder, odorless and tasteless.
- Solubility: Easily soluble in water, slightly soluble in methanol and ethanol, insoluble in acetone and ether.
- Boiling Point: Decomposes (approximately 270℃).
- Melting Point: 290-295℃.
- Stability: Stable when stored in a cool, dry place, avoiding high temperatures, humidity, and light.
- Safety: Low toxicity or practically non-toxic, high safety.
Highassay’s α-Cyclodextrin
- Highassay is a Chinese supplier of α-cyclodextrin, offering various grades of α-cyclodextrin raw materials.
- α-Cyclodextrin is composed of six glucose units with a small encapsulation diameter, making it suitable for encapsulating small molecules.
- α-Cyclodextrin is a product of glucosyltransferase acting on starch syrup and is often used in applications requiring high solubility of cyclodextrins.
- As a functional ingredient in the food industry, α-Cyclodextrin offers dual value in process improvement and blood sugar and lipid control, giving it a unique position in the field of health food additives.
- α-Cyclodextrin is a mainstay in food processing, small molecule pharmaceutical formulations, and environmental remediation. However, due to its small encapsulation diameter and limited capacity, α-Cyclodextrin requires the use of β-Cyclodextrin/γ-Cyclodextrin or synthetic derivatives when encountering large molecule drugs or ultra-large organic pollutants.
Supplementary Technical Details for α-Cyclodextrin
- Production Method: Obtained by enzymatic hydrolysis and purification of starch under the action of cyclodextrin glucosyltransferase (CGTase).
- Acute Toxicity (LD50): Oral LD50 in rats: >20000 mg/kg (practically non-toxic)
- Chronic Toxicity: High safety for long-term use, FDA GRAS certified, meets food-grade standards.
- Upstream and Downstream Products (Raw Materials): Starch, cyclodextrin glucosyltransferase (CGTase), buffers
- Upstream and Downstream Products (Downstream): Food, pharmaceuticals, cosmetics, feed
- Quality Standards: Complies with relevant standards such as USP, EP, FCC, and GB.
- Detection Methods: HPLC, UV, IR, etc. (adjusted according to product characteristics)
- Technical Support: Provides product application technical guidance and solutions.
- After-Sales Service: Provides comprehensive after-sales service and technical support.
Packaging and Storage of α-Cyclodextrin
- Packaging: 1kg/aluminum foil bag, 5kg/carton, 25kg/cardboard drum (lined with polyethylene bag)
- Storage: Store in a cool, dry, and well-ventilated warehouse; keep sealed.
- Shelf Life: 24 months from the production date under proper storage conditions.
- CAS No.: 10016-20-3
- Molecular Formula: C₃₆H₆₀O₃₀
- Standards: Enterprise standard or national standard
- Precautions: Avoid storage with strong oxidizers; wear protective equipment during handling.
- Shipping Method: Sea freight, air freight, express delivery (according to customer needs)
- Payment Method: T/T, L/C, Western Union, etc. (negotiable)
- Certifications: ISO9001, GMP, FDA GRAS, etc. (according to company qualifications)
- After-sales Service: Provide COA and MSDS
α-Cyclodextrin Testing Standards
- α-Cyclodextrin Testing Standards
| CAS NO. | 10016-20-3 |
| Testing Basis | Enterprise Standard |
| Testing Items | Indicators |
| Appearance | This product is a white or off-white amorphous or crystalline powder, readily soluble in water and propylene glycol, almost insoluble in ethanol and dichloromethane. |
| Identification | Optical Rotation: +147°–+152° |
| Liquid Chromatography | The retention time of the main peak in the sample solution is consistent with that of the standard solution. |
| Iodine Reaction | A yellowish-brown precipitate forms. |
| Solution Clarity | 10 mg/ml aqueous solution should be clear. |
| pH Value | 5.0～8.0 |
| Content | 98.0%-101.0% |
| Impurity Absorbance | Not exceeding 0.10 in the wavelength range of 230-350nm; not exceeding 0.05 in the wavelength range of 350-750nm |
| Reducing Sugar | ≤0.2% |
| Moisture | ≤11.0% |
| Betacyclodextrin | ≤0.25% |
| Gammacyclodextrin | ≤0.25% |
| Other Related Substances | ≤0.5% |
| Total Aerobic Bacteria (CFU/g) | ≤1000 |
| Total Yeast and Mold (CFU/g) | ≤100 |
Applications of α-Cyclodextrin
α-Cyclodextrin in Food Sector
- Food-grade α-Cyclodextrin is used as a functional food additive.It helps improve intestinal function and can help prevent problems such as enteritis, colon cancer, dysentery, and constipation.
- Food-grade α-Cyclodextrin is an effective raw material for blood sugar-lowering health foods.It has a good effect on preventing and improving diabetes.
- Food-grade α-Cyclodextrin is a high-performance processing aid in the food processing industry.It can be used for food quality improvement, pigment stabilization, and active ingredient delivery.For example, in bayberry wine, α-Cyclodextrin can delay the degradation of anthocyanins and maintain the color of the wine.
α-Cyclodextrin in Pharmaceutical Field
- Pharmaceutical-grade α-Cyclodextrin is a core excipient for small molecule drugs.It has the advantages of small molecule inclusion, high water solubility, and low intestinal adsorption.
- Pharmaceutical-grade α-cyclodextrin is a functional excipient used in the preparation of oral formulations such as tablets, capsules, granules, powders, and traditional Chinese medicine.It helps to mask the odor of drugs and improve bioavailability.
- Pharmaceutical-grade α-cyclodextrin can be used as a drug carrier.Examples include hydrophobic antitumor drug carriers, nanomedicine carriers, supramolecular hydrogels, or as dry emulsions for mucosal delivery.
α-Cyclodextrin in Industrial Sector
- Industrial-grade α-Cyclodextrincan be used for the efficient removal of pollutants from industrial wastewater, contaminated soil, and organic waste gas.For example, the separation of heavy metal ions.
- Industrial-grade α-Cyclodextrincan be used in the preparation of composite adsorbent materials.Compared with traditional adsorbents, α-Cyclodextrin has stronger targeting and is renewable and reusable, making it a green and multifunctional raw material.
- Industrial-grade α-Cyclodextrinis a production aid in many fields,like textiles, papermaking, and chemicals.While optimizing product performance and improving production efficiency, we can also reduce production costs and environmental pollution.
α-Cyclodextrin in Cosmetics
α-Cyclodextrin is a natural functional excipient used in all categories of cosmetics and skincare products.It can be added directly and has multiple functions such as oil control and cleaning, slow release, odor masking, formula stabilization, and solubilization.It helps improve the skin feel and skincare effects, and is safe, natural, and easy to process.
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