A Brief Introduction to Salcaprozate Sodium
Molecular Formula:C15H22NNaO4
Molecular Weight:303.33
CAS No.:203787-91-1
Appearance:White to off-white solid powder
What is Salcaprozate Sodium?
- Abbreviated as SNAC, it is also known as sodium 8-[(2-hydroxybenzoyl)amino]octanoate.
- It is a fatty acid derivative that is artificially synthesized through organic chemical reactions of caprylic acid or its derivatives with salicylic acid derivatives and other raw materials.
- As a penetration enhancer additive, it is a safe pharmaceutical excipient. SNAC acts in the gastrointestinal tract, targeting both the drug and intestinal epithelial cells.
- It has opened the door to oral absorption for many peptide-based injectable drugs, the most successful example being oral Semaglutide tablets.
Highassay’s Salcaprozate Sodium
Highassay is a SNAC raw material supplier from China. Our raw materials are in the form of a white or off-white solid powder. As an oral peptide drug absorption enhancer, the quality, efficacy, and safety of SNAC are of utmost importance.
Highassay’s SNAC boasts a raw material purity of 99% or higher, with impurities (such as moisture, residual solvents, and inorganic salts) controlled to extremely low levels.We possess sophisticated production processes and complete supporting production equipment, which ensures the stable physical and chemical properties of products across different batches and guarantees a long-term supply of our products.Along with the product, we will provide complete data documentation, analysis certificates, quality assurance documents, and system certification documents. Furthermore, the entire Highassay team will assist you in resolving any issues encountered during the product manufacturing process and provide the most professional advice.
Choosing Highassay saves you time and effort while guaranteeing product quality. Choosing us will be the best decision you make. Because selecting the right SNAC supplier not only provides you with high-quality SNAC raw materials but also allows you to leverage the manufacturer’s professional expertise to accelerate drug development.
What is Semaglutide?
- Semaglutide is available in both injectable and tablet(Under the action of SNAC accelerator)forms.
- Semaglutide tablets are the most representative oral form of GLP-1RA and are primarily used to improve glycemic control in adult patients with type 2 diabetes.Compared to injections,With the assistance of SNAC, the convenience of taking tablets and patient compliance are far superior to that of injectable forms.
- For the treatment of obesity, semaglutide in injectable form has received official approval for long-term weight management in overweight adults.Although oral semaglutide tablets have not yet received official approval, they are already in the clinical research phase and represent a potential future development direction.
The role of SNAC in Semaglutide
Semaglutide is a large-molecule drug, and large-molecule drugs generally have very poor oral absorption and are easily digested and destroyed in the gastrointestinal tract, so they are usually administered by injection. However, with the addition of SNAC, it not only prevents semaglutide from being digested by stomach acid but also helps semaglutide quickly pass through the stomach wall and reach the bloodstream. It is the presence of SNAC that transforms semaglutide from an impossible-to-take oral medication into a miraculous oral tablet.
Applications of Salcaprozate Sodium
Highassay adheres to strict quality control (QC) to produce Salcaprozate Sodium. Buy Salcaprozate Sodium in bulk from us now to get competitive market prices.
SNAC is an important excipient in Semaglutide tablets.Its unique molecular structure allows SNAC to form stable, more lipophilic complexes with drug molecules, protecting the drug from degradation in the gastrointestinal tract and enabling it to reach the bloodstream directly. This significantly improves the oral bioavailability of the drug, fundamentally solving the problem of poor drug absorption.
It is an important excipient in oral octreotide capsules.The American company Chiasma developed a drug absorption enhancement platform based on the characteristics of SNAC and successfully prepared oral octreotide with SNAC as a component. In 2020, the U.S. FDA approved the octreotide enteric-coated capsules for the treatment of acromegaly.
SNAC is being used in the development of oral medications for insulin, growth hormone, and other peptides; as an oral absorption enhancer, it has the potential to become a delivery agent for oral forms of heparin and insulin.
SNAC technology can serve as a research platform for the development of other oral macromolecular drugs, not only reducing research and development risks but also lowering development costs.
SNAC has relatively few side effects, mainly manifesting as mild gastrointestinal reactions such as nausea and diarrhea. These mild side effects usually disappear or subside on their own within a short time.
SNAC is readily soluble in water and organic solvents, and its solubility varies with pH. It is most stable and has optimal solubility in neutral to slightly alkaline environments.
SNAC works by regulating the local pH value in the gastrointestinal tract, reducing the risk of drug degradation; it also improves drug permeability, facilitating the passage of large molecules or poorly lipid-soluble drugs across the intestinal wall into the bloodstream. This allows traditionally orally administered drugs that are difficult to absorb to exert their effects without the need for injection.
Specification of Salcaprozate Sodium
| Product Name | Salcaprozate Sodium |
| Synonyms | SNAC |
| Solubility | Easily soluble in water and organic solvents |
| Melting Point | 180-220℃ |
| Shape | Solid |
| Toxicity | As a pharmaceutical excipient, its safety has been clinically proven |
| Package | Use moisture-proof and light-blocking sealing materials |
| Storage | Store in a cool, dry, dark, and well-ventilated place |
