Basic Information of R-(+)-Lipoic Acid
- Product Name: R-(+)-Lipoic Acid
- English aliases: R-alpha-Lipoic acid, (R)-5-(1,2-Dithiolan-3-yl)pentanoic acid, Natural lipoic acid, R-Lipoic Acid, R-(+)-Lipoic Acid, Natural lipoic acid, R-alpha lipoic acid
- Industry Abbreviations: R-ALA, Natural Alpha-Alpha
- Other language names: German: R-(+)-Liponsäure; French: Acide R-(+)-lipoïque; Spanish: Ácido R-(+)-lipoico
- CAS number: 1200-22-2
- Molecular Formula: C₈H₁₄O₂S₂
- Molecular Weight: 206.33 g/mol
- Product Grade: Pharmaceutical grade, Food grade, Industrial grade, Cosmetic grade
- Main uses: Nutritional supplements, Food additives, Pharmaceutical intermediates, Cosmetic raw materials
- Supplier : Changzhou Highassay Chemical Co., Ltd.
Physicochemical Properties of R-(+)-Lipoic Acid
- Appearance and smell: White to pale yellow crystalline powder with a distinctive odor.
- Solubility: Easily soluble in chloroform, ether, and ethanol; soluble in acetone; slightly soluble in water; insoluble in petroleum ether.
- Boiling Point: 160-165℃ (0.1 mmHg, decomposition)
- Melting Point: 48-52℃
- Density: 1.13-1.16 g/cm³ (solid crystal density)
- Purity: ≥99% (pharmaceutical grade), optical purity ≥99%ee
- Other Features: +115° to +125° (c=1, ethanol)
- Stability: Store in a cool, dry place where it is stable, avoiding high temperatures, humidity, and light.
- Danger: Low toxicity or practically non-toxic; some products may cause slight irritation.
- Emergency Response: Skin contact: Rinse immediately with plenty of water; Ingestion: Seek immediate medical attention.

Supplementary Technical Details for R-(+)-Lipoic Acid
- Production Methods: The product is prepared by chiral synthesis or biotransformation and purified by chiral chromatography to obtain a high optical purity product.
- Acute Toxicity (LD50): Oral LD50 in rats: 500-550 mg/kg (low toxicity); Oral LD50 in mice: 520-580 mg/kg
- Chronic Toxicity: Long-term use is safer than the racemic form and meets pharmaceutical-grade USP and EP standards.
- Upstream and downstream products (raw materials): Chiral intermediates, sulfiding agents, catalysts
- Upstream and downstream products (downstream): High-end antioxidant health products, pharmaceutical preparations, cosmetic raw materials, and biological reagents
- Quality Standards: Compliant with USP, EP, and GB
- Detection Methods: HPLC, UV, IR, etc.
- Transportation Methods: Sea freight, air freight, and express delivery
- Payment Methods: T/T, L/C, Western Union, etc.
- Certification Status: ISO9001, GMP, kosher halal etc.
- Technical Support: Provide product application technical guidance and solutions
Packaging and Storage of R-(+)-Lipoic Acid
- Packaging: 25kg/fiber drum (lined with polyethylene bag), or according to customer requirements
- Storage: Store in a cool, dry, and well-ventilated warehouse; avoid direct sunlight and moisture
- Shelf Life: 24 months from the production date under proper storage conditions
- CAS number: 1200-22-2
- Molecular Formula: C₈H₁₄O₂S₂
- Molecular Weight: 206.33 g/mol
- Implementation Standards: Enterprise standards or USP/BP/EP/CP
- Precautions: Avoid storing with strong oxidizers, strong acids, or strong alkalis; wear protective equipment during operation.
- After-sales Service: Provides COA and MSDS; free returns and exchanges for quality issues; technical support.

Applications of R-(+)-Lipoic Acid
Pharmaceutical Field:
- Pharmaceutical grade R-(+)-Lipoic Acid raw material plays an important role in the treatment of diabetic peripheral neuropathy and as an adjunct therapy for diabetes and its complications. It can be used as a core component in hepatoprotective drugs and nerve repair drugs.
- Pharmaceutical grade R-(+)-Lipoic Acid, as an enzyme activity regulator, plays an important role in biocatalytic reaction research.
Food Sector:
- Food-grade R-(+)-Lipoic Acidis manufactured into nutritional supplements in the form of capsules, tablets, etc..It is suitable for consumers with specific needs such as antioxidant benefits and neurological health support.
- Food-grade R-Lipoic Acidis used as one of the ingredients in foods for special medical purposes.Suitable for people with diabetes, peripheral neuropathy, and other conditions.As one of the intervention methods in medical nutrition.
- Food-grade R-Lipoic Acid can be used in the food processing industry for antioxidant preservation of oils, baked goods, beverages.
- Food-grade or feed-grade R-(+)-Lipoic Acidis used as an additive in livestock and poultry feed to improve the animals’ immunity and antioxidant capacity.
Cosmetics Field:
- Cosmetic grade R-(+)-Lipoic Acid is an ingredient used in mid-to-high-end, functional skincare products. It possesses multi-target, highly effective anti-aging and skin repair functions and is commonly used in serums, lotions, and creams.
- Cosmetic grade R-(+)-Lipoic Acid can be used in products for post-medical aesthetic procedures to soothe oxidative stress damage.
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