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Basic information of Methyl-β-cyclodextrin

Product Name: Methyl-β-cyclodextrin
English Aliases: Methyl-Beta-Cyclodextrin; Methyl-β-Cyclodextrin; Methyl Cyclodextrin; beta-Cyclodextrin methylethers; beta-Cyclodextrin methyl ethers, methyl β-cyclodextrin
Industry Abbreviations: Me-β-CD, mβcd, MβCD
CAS No.: 128446-36-6
Molecular Formula: C42H70-nO35 · (CH3)n
Molecular Weight: 1135 + n•(14.0)
EINECS No.: 1308068-626-2
Product Grades: Pharmaceutical Grade, Food Grade, Cosmetic Grade, Reagent Grade, Industrial Grade
Main Uses: Pharmaceutical excipient (solvent), cholesterol-consuming reagent, nanocarrier, food additive, cosmetic additive, cell culture additive, industrial auxiliary agent, etc.

Methyl-β-cyclodextrin is abbreviated as Me-β-CD or mβcd.
Methyl-β-cyclodextrin is a derivative of β-cyclodextrin, introduced by the methyl group.
Key characteristics of methyl-β-cyclodextrin: strong hydrophobic cavities, strong biological activity, and cholesterol-lowering effects.
Methyl-β-cyclodextrin can be used in pharmaceuticals, food, cosmetics, and other industries; its superior ability compared to other cyclodextrins lies in its ability to encapsulate oil-soluble molecules.
Highassay is a Chinese supplier of methyl-β-cyclodextrin raw materials. Our company primarily supplies injection-grade methyl-β-cyclodextrin raw materials, with other grades as supplementary suppliers. If you need to purchase methyl-β-cyclodextrin, please select Highassay.

Production Method: β-Cyclodextrin is methylated with dimethyl sulfate under alkaline conditions, followed by purification and crystallization.
Acute Toxicity (LD50): Oral LD50 in rats: >2000 mg/kg (low toxicity); Oral LD50 in mice: >5000 mg/kg
Chronic Toxicity: High safety with long-term use, no cumulative toxicity, meets pharmaceutical/food grade standards
Upstream and Downstream Products (Raw Materials): Upstream: β-Cyclodextrin, dimethyl sulfate, sodium hydroxide; Downstream: Pharmaceutical preparations, food additives
Transportation Conditions: General cargo transportation, avoid extreme temperatures (<0℃ or >30℃) and severe vibration.
Transportation Methods: International: Sea freight, air freight, international express (DHL/FedEx/UPS); Domestic: Logistics, express delivery
Payment Terms: T/T, L/C (letter of credit), PayPal (small payments)
Certifications: ISO9001 Quality Management System Certification, GMP Pharmaceutical Production Certification, FDA Food Contact Certification

Appearance and Odor: White to off-white powder, odorless or slightly sweet.
Solubility: Easily soluble in water (above 200 g/L), soluble in methanol/ethanol, insoluble in ether/chloroform.
Boiling Point: Decomposes above 200℃ (no definite boiling point).
Melting Point: 130-140℃ (decomposition point).
Specific Rotation: +160° ~ +170° (c=1, H₂O).
pH Value: 5.0-8.0 (1% aqueous solution, 25℃).
Residue on Ignition: Pharmaceutical grade ≤0.1%, food grade ≤0.3%, industrial grade ≤0.5%.
Stability: Stable in solid state; aqueous solution is stable for 7 days at 4℃; recommended for use within 24 hours at room temperature.
Hazards: Low toxicity, non-irritating, non-flammable and non-explosive, high safety level (GHS classification: None).

Packaging: 25kg/cardboard drum (lined with polyethylene bag), 1kg/aluminum foil bag, 100g/reagent bottle
Storage: Store in a cool, dry place at 2-8℃, protected from light and moisture. Use as soon as possible after opening.
Shelf Life: 36 months (from the date of production) under recommended storage conditions.
CAS No.: 128446-36-6
Product Standards: USP (United States Pharmacopeia), EP (European Pharmacopeia), CP (Chinese Pharmacopeia), FCC (Food Chemicals Codex Alimentarius Commission)
Quality Testing: HPLC purity analysis, IR infrared identification, moisture determination, heavy metal detection, microbial limit testing
Precautions: Avoid contact with strong oxidizing agents; use with caution in patients allergic to cyclodextrin; aqueous solutions should be prepared and used immediately.
After-sales Service: Provides COA (Analysis Report) and MSDS (Material Safety Data Sheet); unconditional return and exchange for quality issues.

Pharmaceutical-grade methyl-β-cyclodextrin can be used as a solubilizer and absorption enhancer for drugsEnhancing drug solubility and bioavailability by forming inclusion complexes.It is mainly used as an additive in injections, oral medications, topical medications, and intracavitary drug delivery systems.
Pharmaceutical-grade methyl-β-cyclodextrin has a cholesterol-regulating effect.It is a cholesterol-consuming reagent, administered directly by injection.
Pharmaceutical-grade methyl-β-cyclodextrin can be used as a carrier for constructing nanomedicines for drug delivery.
Food-grade methyl-β-cyclodextrin is used as a food additive.It can effectively remove odors and stabilize fragrances and pigments.
Cosmetic-grade methyl-β-cyclodextrin is used as an additive in cosmetics.It can effectively protect the active ingredients of cosmetics and reduce skin irritation.
Reagent-grade methyl-β-cyclodextrin can be used as an additive for cell culture.Increases the solubility ofsomething like fatty acids, lipids, and vitamins in the culture medium.
Reagent-grade methyl-β-cyclodextrin can be used as a basic tool in various research fields.For example, its effects on cardiomyocytes; its effects on human corneal stromal fibroblasts, etc.

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