What is L-Leucine?
L-Leucine is an essential amino acid that cannot be synthesized naturally and must be obtained through diet or leucine supplements. L-Leucine is found in almost all meat-based foods, as well as dairy products and legumes. However, it is found in very low or even no amounts in plant-based foods. Therefore, it can be difficult for the elderly, vegetarians, or those with picky eaters to obtain sufficient L-Leucine from their daily diet. It is recommended to supplement with leucine-containing nutritional supplements or blended supplements to maintain amino acid balance and enhance health.
Benefits of L-Leucine
- L-Leucine is rapidly broken down into glucose in the body, providing energy. Glucose is not only a direct energy source for cellular metabolism but also participates in the metabolism of fat and protein, maintaining overall metabolic balance.
- L-Leucine promotes protein synthesis, aids muscle recovery, and maintains muscle performance and strength. Moderate leucine supplementation is particularly beneficial for professional athletes and sports enthusiasts. It is recommended to supplement with valine and isoleucine.
- L-Leucine also has weight loss and body shaping benefits. By boosting metabolism and protein synthesis, it can reduce body fat and increase muscle protein, leading to weight loss, a goal difficult to achieve through dieting or exercise alone.
- L-Leucine has antioxidant properties and can enhance the activity of antioxidant enzymes. It is often used in anti-inflammatory products.
If you have any questions about processing L-Leucine, Highassay’s R&D team is here to help.
A Brief Introduction to L-Leucine
Molecular Formula：C6H13NO2
Molecular Weight：131.17
CAS No.：61-90-5
Appearance：White shiny hexahedral crystals or white crystalline powder
Regular commercial package: 25kg/drum
Applications of L-Leucine
Highassay adheres to strict quality control (QC) to produce L-Leucine. Buy L-Leucine in bulk from us now to get competitive market prices.
Food AdditivesIn addition to being added to nutritional supplements, it is also used in bread and pasta to enhance flavor and provide a small amount of L-Leucine.
Animals and PlantsIn addition to being used as a nutritional additive in animal feed, it can also be used in the preparation of plant growth promoters.
PharmaceuticalsIt is used in the preparation of amino acid infusions, combined amino acid preparations, and hypoglycemic agents.
Symptoms of L-Leucine Deficiency
L-Leucine regulates blood sugar levels. Low L-Leucine levels in the body can cause symptoms similar to hypoglycemia, such as headaches, dizziness, fatigue, depression, irritability, and other neurological problems. Therefore, if you cannot get enough L-Leucine through a normal diet, it is recommended to take a supplement.
The Daily L-Leucine Dosage Required by an Average Adult
The average adult requires approximately 2000 mg of L-Leucine daily, supplemented in divided doses. Exceeding 2000 mg is not recommended to prevent a range of side effects, such as increased burden on the kidneys and liver, and impacted gastrointestinal function, leading to gastrointestinal disorders.
Storage of L-Leucine
Store in a sealed container in a dry, cool, and dark place away from light. Do not mix or transport with toxic or hazardous substances. This product is non-hazardous and can be transported like general chemicals. Handle with care and protect from sunlight and rain.
Specification of L-Leucine
| L-Leucine | CP2020 | EP11 | USP2023 | USP24 | AJI92 | High Purity | Instant | Granulation |
| Assay | ≥98.5% | 98.5-101.0% | 98.5-101.5% | 98.5-101.5% | 99.0-100.5% | ≥98.5% | ≥95.0% | ≥95% |
| PH | 5.5-6.5 | / | 5.5-7.0 | 5.5-7.0 | 5.5-6.5 | / | / | / |
| Lecithin | / | / | / | / | / | / | 0.5～1.0% | / |
| Binder content | / | / | / | / | / | / | / | ≤5% |
| Specific rotation[a]D20 | +14.9°-+16.0° | +14.5°-+16.5° | / | / | +14.9°-+16.0° | +14.9°-+16.0° | / | / |
| Specific rotation[a]D25 | / | / | +14.9°-+17.3° | +14.9°-+17.3° | / | / | / | / |
| Transmittance(T430) | ≥98.0% | / | / | / | ≥98.0% | ≥98.0% | ≥98.0% | / |
| Appearance of solution | / | clear & colorless ≤BY6 | / | / | / | / | / | / |
| Bulk Density | / | / | / | / | / | / | ≥0.25g/ml | ≥0.50g/ml |
| Tapped Density | / | / | / | / | / | / | ≥0.30g/ml | ≥0.55g/ml |
| Chloride(Cl) | ≤0.02% | ≤0.02% | ≤0.05% | ≤0.05% | ≤0.02% | ≤0.01% | / | / |
| Ammonium(NH4) | ≤0.02% | ≤0.02% | / | / | ≤0.02% | / | / | / |
| Sulfate(SO4) | ≤0.02% | ≤0.03% | ≤0.03% | ≤0.03% | ≤0.02% | ≤0.02% | / | / |
| Iron(Fe) | ≤10PPM | ≤10PPM | ≤30PPM | ≤30PPM | ≤10PPM | / | / | / |
| Heavy metals(Pb) | ≤10PPM | / | / | ≤15PPM | ≤10PPM | / | ≤10ppm | ≤10ppm |
| Arsenic | ≤1PPM | / | / | ≤1.5PPM | ≤1PPM | / | ≤1ppm | ≤1ppm |
| Lead | / | / | / | / | / | / | ≤3ppm | ≤3ppm |
| Cadmium | / | / | / | / | / | / | ≤1ppm | ≤1ppm |
| Mercury | / | / | / | / | / | / | ≤0.3ppm | ≤0.1ppm |
| Other amino acids | ≤0.5% | / | Individual impurities≤0.5% Total impurities≤2.0% | / | conforms | Individual impurities≤0.2% Total impurities≤1.0% | / | / |
| Ninhydrin-positive substances | / | Impurity A at 570 nm≤0.8% Each impruity ≤0.2% Total ≤1.0% | / | / | / | / | / | / |
| Particle Size Range | / | / | / | / | / | / | ≥95% through 80 mesh | ≥90% through 20 mesh ≤30% through 80 mesh |
| Loss on drying | ≤0.20% | ≤0.50% | ≤0.2% | ≤0.2% | ≤0.20% | ≤0.20% | ≤1.0% | ≤2.0% |
| Residue on ignition | ≤0.10% | ≤0.10% | ≤0.4% | ≤0.4% | ≤0.10% | / | ≤0.50% | ≤0.4% |
| Organic volatile impurities | / | / | / | conforms | / | / | / | / |
| Endotoxin | <25EU/g | <25EU/g | <25EU/g | / | / | / | / | / |
| Total plate count | ≤ 1000 CFU/g | ≤ 1000 CFU/g | ≤ 1000 CFU/g | ≤ 1000 CFU/g | ≤ 1000 CFU/g | ≤ 1000 CFU/g | ≤ 1000 CFU/g | ≤ 1000 CFU/g |
| Moulds & Yeasts | ≤ 100 CFU/g | ≤ 100 CFU/g | ≤ 100 CFU/g | ≤ 100 CFU/g | ≤ 100 CFU/g | ≤ 100 CFU/g | ≤ 100 CFU/g | ≤ 100 CFU/g |
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Groups not recommended for leucine supplementation:
- Patients with diabetes or maple syrup urine disease
- Pregnant or breastfeeding women
- Children
- People with kidney or liver problems
The Relationship Between Leucine, Isoleucine, and Valine
Leucine, Isoleucine, and Valine together make up the branched-chain amino acids (BCAAs), all of which are essential amino acids. BCAAs play important roles in protein synthesis and energy metabolism.
