A Brief Introduction to L-Histidine
Molecular Formula： C6H9N3O2
Molecular Weight：155.16
CAS No.： 71-00-1
Appearance：White or off-white crystals or crystalline powder
Regular commercial package: 25kg/drum
Benefits of L-Histidine
- L-Histidine is involved in the synthesis of hemoglobin, which is crucial for maintaining human health. Therefore, a sufficient amount of L-Histidine ensures sufficient hemoglobin to support normal gas exchange and metabolism.
- L-Histidine plays a key role in promoting iron absorption, alleviating anemia symptoms and boosting immunity.
- L-Histidine has a significant effect on regulating gastric acid, protecting the stomach and intestines by increasing gastric juice.
- L-Histidine promotes keratin synthesis, improving the condition of hair and skin, and building a barrier to protect the skin from moisture loss.
If you have any questions about processing L-Histidine, Highassay’s R&D team is here to help.
What is L-Histidine?
L-Histidine is a basic amino acid containing an imidazole functional group. It’s unique in that adults can synthesize it naturally, but infants and young children cannot. Therefore, infants and children with uremia require additional L-Histidine supplementation to maintain amino acid balance in their bodies. A deficiency in L-Histidine can lead to diseases such as histidinemia and affect the normal development of the nervous system.
Application of L-Histidine
Highassay adheres to strict quality control (QC) to produce L-Histidine. Buy L-Histidine in bulk from us now to get competitive market prices.
Animal FeedAdding L-Histidine to animal feed promotes digestion and improves the absorption of nutrients in the feed.
PharmaceuticalsIt is used in the form of infusions and tablets for the prevention and treatment of diseases such as anemia and gastric ulcers.
CosmeticsL-Histidine is widely used in various cosmetics, such as creams and serums, due to its safety, antioxidant properties, and moisturizing properties.
Food AdditivesIt is manufactured into nutritional supplements for direct consumer consumption, making L-Histidine supplementation more convenient; it is also added to fermented foods to enhance their taste.
Medical ResearchIt is used in the form of solutions and reagents for various biological and chemical studies.
Source and Dosage of L-Histidine
L-Histidine is commonly found in most common foods, primarily meats, dairy products, legumes, and nuts. It is found in lower concentrations in fruits and green vegetables. Therefore, it can be difficult for vegetarians to obtain sufficient L-Histidine for human use and synthesis through their daily diet. Besides daily food intake, a faster and more effective way is to supplement directly with L-Histidine or mixed amino acid supplements. The daily dosage for adults is 2-4 grams, but should not exceed 4 grams. The specific intake should be determined based on the individual’s individual needs. Supplementation is not recommended for pregnant women, lactating women, or those with folic acid deficiency.
Storage of L-Histidine
- Store in a cool, airtight container in a well-ventilated environment to prevent moisture and loss of efficacy.
- Highassay has complete L-Histidine production facilities, transportation, and storage facilities. Buy L-Histidine in bulk from us now to get competitive market prices.
L-Histidine Hydrochloride VS L-Histidine
L-Histidine hydrochloride is produced by reacting L-Histidine with hydrochloric acid. It is commonly used as an amino acid supplement to boost the immune system, promote growth and development, and accelerate wound healing. While L-Histidine hydrochloride is generally considered safe, direct contact with skin and eyes should be avoided.
Histidinemia is an autosomal recessive genetic disorder. While some patients may have no obvious symptoms, others experience a range of symptoms, including intellectual disability, speech impairment, and motor delay.
L-Histidine supplementation can alleviate eczema symptoms to a certain extent. However, the likelihood of eradication or a cure is relatively low, as eczema is caused by a variety of factors and is a chronic condition. All we can do is maintain skin moisturization.
First, their structures and polarity differ. Second, their primary functions in the human body are also different. Please choose wisely and supplement appropriately based on your needs.
Specification of L-Histidine
| L-Histidine | CP2020 | EP11 | USP2023 | USP32 | AJI92 |
| Assay | ≥ 99.0% | 98.5-101.0% | 98.5-101.5% | 98.5-101.5% | 99.0-101.0% |
| PH | 7.0-8.5 | / | 7.0-8.5 | 7.0-8.5 | 7.0-8.5 |
| Specific rotation[a]D20 | +12.0°-+12.8° | +11.4°-+12.4° | / | / | +12.0°-+12.8° |
| Specific rotation[a]D25 | / | / | +12.6°-+14.0° | +12.6°-+14.0° | |
| Transmittance(T430) | ≥ 98.0% | / | / | / | clear & colorless ≥ 98.0% |
| Appearance of solution | / | clear & colorless ≤BY7 | / | / | / |
| Chloride(Cl) | ≤0.02% | ≤0.02% | ≤0.05% | ≤0.05% | ≤0.02% |
| Ammonium(NH4) | ≤0.02% | ≤0.02% | / | / | ≤0.02% |
| Sulfate(SO4) | ≤0.02% | ≤0.03% | ≤0.03% | ≤0.03% | ≤0.02% |
| Iron(Fe) | ≤10PPM | ≤10PPM | ≤30PPM | ≤30PPM | ≤10PPM |
| Heavy metals(Pb) | ≤10PPM | / | / | ≤15PPM | ≤10PPM |
| Arsenic | ≤1PPM | / | / | / | ≤1PPM |
| Other amino acids | ≤0.5% | / | Individual impurities≤0.5% Total impurities≤2.0% | Individual impurities≤0.5% Total impurities≤2.0% | conforms |
| Ninhydrin-positive substances | / | Each impurities≤ 0.2% Total impurities≤ 0.5% | / | / | |
| Loss on drying | ≤0.20% | ≤0.50% | ≤0.20% | ≤0.20% | ≤0.20% |
| Residue on ignition | ≤0.10% | ≤0.10% | ≤0.40% | ≤0.40% | ≤0.10% |
| Endotoxin | ＜6 EU/g | ＜6 EU/g | ＜6 EU/g | / | / |
| Total plate count | ≤ 1000 CFU/g | ≤ 1000 CFU/g | ≤ 1000 CFU/g | ≤ 1000 CFU/g | ≤ 1000 CFU/g |
| Moulds & Yeasts | ≤ 100 CFU/g | ≤ 100 CFU/g | ≤ 100 CFU/g | ≤ 100 CFU/g | ≤ 100 CFU/g |
