Basic Information of L-5-Methyltetrahydrofolate Calcium
- Product Name: L-5-Methyltetrahydrofolate Calcium
- English aliases: Calcium L-5-methyltetrahydrofolate, L-5-MTHF calcium salt, Calcium levomefolate, L-Methylfolate Calcium, L-5-MTHF Calcium, Active folate, Calcium methylfolate
- Industry Abbreviations: L-5-MTHF-Ca, Active Folic Acid Calcium
- Other language names: German: Calcium-L-5-Methyltetrahydrofolat; French: Calcium L-5-méthyltétrahydrofolate; Spanish: Calcio L-5-metiltetrahidrofolato
- CAS number: 151533-22-1
- Molecular Formula: C₂₀H₂₃CaN₇O₆·xH₂O (x≈3)
- Molecular Weight: Approximately 511.56 g/mol (anhydrous)
- Product Grade: Pharmaceutical grade, Food grade, Industrial grade, Cosmetic grade
- Main uses: Nutritional supplements, Food additives, Pharmaceutical intermediates, Cosmetic raw materials
Physicochemical Properties of L-5-Methyltetrahydrofolate Calcium
- Appearance and smell: Grayish-white to light yellow solid powder, odorless or with a slight special odor.
- Solubility: Easily soluble in dilute acids, soluble in water (solubility approximately 5 g/100 mL at 25°C), slightly soluble in ethanol, and insoluble in ether.
- Boiling Point: Decomposition (decomposition above 200℃)
- Melting Point: 170-175℃ (decomposes)
- Density: 1.58-1.62 g/cm³ (solid crystal density)
- Purity: ≥98% (pharmaceutical grade), optical purity ≥99%ee
- Stability: Store in a cool, dry place where it is stable, avoiding high temperatures, humidity, and light.
- Danger: Low toxicity or practically non-toxic; some products may cause slight irritation.
- Emergency Response: Skin contact: Rinse immediately with plenty of water; Ingestion: Seek immediate medical attention.
Supplementary Technical Details for L-5-Methyltetrahydrofolate Calcium
- Production Methods: The product is produced using a biotransformation method, through fermentation with genetically engineered bacteria, followed by purification and salt formation to obtain the calcium salt product.
- Acute Toxicity (LD50): Oral LD50 in rats: >5000 mg/kg (practically non-toxic); Oral LD50 in mice: >8000 mg/kg
- Chronic Toxicity: It has a high safety profile for long-term use, is suitable for people with MTHFR gene defects, and meets pharmaceutical-grade USP and EP standards.
- Upstream and downstream products (raw materials): Folic acid, genetically engineered bacteria, culture medium, calcium chloride
- Upstream and downstream products (downstream): Nutritional supplements for pregnant women, medications for treating anemia, health foods, and additives for infant formula.
- Quality Standards: Compliant with USP, EP, and GB
- Detection Methods: HPLC, UV, IR, etc.
- Transportation Methods: Sea freight, air freight, and express delivery
- Payment Methods: T/T, L/C, Western Union, etc.
- Certification Status: ISO9001, GMP, kosher halal etc.
- Technical Support: Provide product application technical guidance and solutions
Packaging and Storage of L-5-Methyltetrahydrofolate Calcium
- Packaging: 25kg/fiber drum (lined with polyethylene bag), or according to customer requirements
- Storage: Store in a cool, dry, and well-ventilated warehouse; avoid direct sunlight and moisture
- Shelf Life: 24 months from the production date under proper storage conditions
- CAS number: 151533-22-1
- Molecular Formula: C₂₀H₂₃CaN₇O₆·xH₂O (x≈3)
- Molecular Weight: Approximately 511.56 g/mol (anhydrous)
- Implementation Standards: Enterprise standards or USP/BP/EP/CP
- Precautions: Avoid storing with strong oxidizers, strong acids, or strong alkalis; wear protective equipment during operation.
- After-sales Service: Provides COA and MSDS; free returns and exchanges for quality issues; technical support.
Applications of L-5-Methyltetrahydrofolate Calcium
Pharmaceutical grade L-5-Methyltetrahydrofolate Calcium
- Pharmaceutical-grade L-5-Methyltetrahydrofolate Calciumcan be used as a core active ingredient in prescription drugs and injections, and is suitable for individuals who are unable to utilize ordinary folic acid due to genetic factors, diseases, or medications, and who experience resulting health problems.
- Pharmaceutical-grade L-5-Methyltetrahydrofolate Calciumcan be used as a component in high-dose medical nutritional supplements.The content of the ingredients varies depending ondifferent purposes of use.
For instance, it is used as a main ingredient in medical nutritional products for treating hyperhomocysteinemia.
For example, it can be used as a key supplementary ingredient for groups requiring comprehensive nutritional support or patients with inefficient folate metabolism.
Food-grade L-5-Methyltetrahydrofolate Calcium
- Food-grade L-5-Methyltetrahydrofolate Calciumcan be used in the production of dietary supplements.L-5-Methyltetrahydrofolate Calciumis available in various forms, including tablets, gummies, and capsules.It is a key ingredient in high-end folic acid supplements and multivitamins (especially those designed for pregnant women and individuals with MTHFR gene mutations).
- Food-grade L-5-Methyltetrahydrofolate Calciumcan be used as an additive in fortified foods.It can be added to prenatal milk powder, cereals, or other solid beverages, replacing the daily supplementation of ordinary synthetic folic acid.
Feed-grade L-5-Methyltetrahydrofolate Calcium
Feed-grade L-5-Methyltetrahydrofolate Calciumcan be added as a feed additive to animal feed or pet food (especially cat and dog food).This helps to provide the specific nutritional needs at different stages of development, thereby improving the reproductive capacity and overall health of the animals and preventing the occurrence of diseases.
Cosmetic grade L-5-Methyltetrahydrofolate Calcium
Cosmetic-grade L-5-Methyltetrahydrofolate Calciumcan be used as a raw material in the development of topical skincare formulations, serving as a component in cosmeceuticals or functional cosmetics.
Reagent-grade L-5-Methyltetrahydrofolate Calcium
Reagent-grade L-5-Methyltetrahydrofolate Calciumcan be used as a reference standard or key reagent in research and testing.
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