A Brief Introduction to Econazole Nitrate
Molecular Formula:C18H16Cl3N3O4( C₁₈H₁₅Cl₃N₂O·HNO₃)
Molecular Weight:444.7
CAS No.:24169-02-6
Appearance:White or slightly yellow crystals or crystalline powder
Regular commercial package: 25kg/drum
What is Econazole Nitrate?
Econazole Nitrate is a broad-spectrum antifungal drug primarily used to treat fungal infections such as dermatophytes and Candida. It is particularly effective against superficial fungal infections, such as tinea pedis and tinea corporis. Econazole Nitrate works by inhibiting fungal cell membrane synthesis and affecting the metabolic processes of the fungal cell membrane, thereby leading to fungal cell death and ultimately curing the fungal infection.
Why choose Highassay?
Highassay provides high-purity, high-quality Econazole Nitrate raw materials. Our Econazole Nitrate raw materials are white or slightly yellow crystalline or crystalline powder, odorless, and readily soluble in methanol but practically insoluble in water. As an antifungal raw material, it exhibits activity against dermatophytes, yeasts and is effective against Gram-positive bacteria. Highassay’s raw materials not only meet GMP standards but also comply with the standards of multiple pharmacopoeias, such as CP, BP, USP, and EP. Choosing our products as your production raw materials will undoubtedly enhance the quality of your products and ensure their widespread popularity.
Formulations of Econazole Nitrate
Highassay’s Econazole Nitrate raw material can be used to produce various types of Econazole Nitrate formulations, the most common being ointments and sprays. In addition, it can also be formulated into suppositories(Primarily used in the vagina), solutions, etc. Regardless of the formulation form or the raw material itself, Econazole Nitrate needs to be stored in a light-proof, airtight container to prevent the decomposition of its activity, which would lead to formulation inactivation.
Compound Econazole Nitrate Cream
Highassay’s Econazole Nitrate raw material can be used not only as the main ingredient in Econazole Nitrate ointment, but also in combination with triamcinolone acetonide to formulate compound Econazole Nitrate cream. Compound Econazole Nitrate ointment, in addition to its antifungal effects, also has anti-inflammatory, anti-allergic, and antipruritic functions. It can be used to treat fungal infections accompanied by severe inflammation, eczema, or allergic reactions. Because it contains hormones, its antipruritic and redness-reducing effects are very significant. However, compound creams should not be used indiscriminately to avoid aggravating the condition or causing side effects; it should be used only after consulting a doctor. Compound Econazole Nitrate cream can be used to treat some types of eczema, such as eczema complicated by fungal infection, neurodermatitis, or some types of chronic eczema; however, long-term use should be avoided.
1% Econazole Nitrate
1% Econazole Nitrate means that the product contains 1% of the active pharmaceutical ingredient, Econazole Nitrate. This ratio is clinically validated and considered the golden ratio. It not only effectively treats conditions caused by fungal and yeast infections but also minimizes skin irritation. When choosing an Econazole Nitrate product, simply look for the prominent label indicating 1% Econazole Nitrate. This largely solves the problem of choice difficulties and ensures the safety and effectiveness of the selected product. Furthermore, as a manufacturer of Econazole Nitrate products, choosing Highassay’s Econazole Nitrate raw materials to produce 1% Econazole Nitrate guarantees the highest quality assurance for your product.
Applications of Econazole Nitrate
Econazole nitrate can be used to treat a variety of fungal infections.
Fungal infections of the feet generally refer to tinea pedis or athlete’s foot. Econazole Nitrate is highly effective in treating these conditions. As long as you follow the correct usage instructions (keep your feet clean and dry, and apply a thin layer to the area 1-2 cm around the affected area) and persist with use, continuing medication for 1-2 days after symptoms disappear, the chances of a complete cure are very high. As an over-the-counter medication, it is readily available through various channels, but it is important to use it only for the specific symptoms.
Tinea versicolor, also known as pityriasis versicolor or sweat rash, is a superficial fungal infection caused by a lipophilic yeast called Malassezia. It initially appears as small spots, gradually developing into patches. While not contagious, tinea versicolor affects appearance. You can treat tinea versicolor with Econazole Nitrate. If your condition is mild, Econazole Nitrate alone may be sufficient. If it is more severe, oral medication may be necessary for faster healing.
Econazole Nitrate is not ideal for treating onychomycosis or nail fungus and is not suitable for its use. Econazole Nitrate cannot penetrate the hard nail to reach the infected area, thus failing to exert its therapeutic effect. Econazole Nitrate is better suited for treating superficial fungal infections.
Common side effects include local irritation and allergic reactions, such as redness, swelling, and itching. Long-term, large-area use rarely causes serious side effects, such as headaches, nausea, or other systemic reactions.
Econazole Nitrate, Clotrimazole, and Ketoconazole are all imidazole antifungal drugs with the same antifungal mechanism. The main differences lie in their safety and potency. Choose the most suitable product based on your specific symptoms and your doctor’s advice.
If it’s for topical use, it can be used on the face, but avoid the mouth, eyes, and nose.
Specification of Econazole Nitrate
| Items | Standards |
| Product Name | Econazole Nitrate |
| Appearance | White or almost white powder |
| Identification | IR, UV conforms |
| Clarity of solution (1% methanol solution) | The solution is clear and not more intensely colored than Y7 |
| Related substances | Each Impurity: 0.25% max Total impurities: 0.5% max |
| Chromatographic purity-individual purity | 0.25% max |
| Ordinary impurities | 2.0% max |
| Melting point | 163-167 D.C. |
| Loss on drying | 0.5% max (105 D.C., 2hours) |
| Residue on ignition | 0.1% max |
| Assay (on dried basis) | 98.0-102.0% |
| Conclusion | Conforms to USP |
