Basic Informations of Dipalmitoyl Hydroxyproline
- Product Name: Dipalmitoyl Hydroxyproline
- English Aliases: N,N-Dipalmitoyl-L-hydroxyproline, Dipalmitoyl-L-hydroxyproline
- Industry Abbreviation: DPHP, Dipalmitoyl Hydroxyproline
- Molecular Formula: C37H69NO5
- Molecular Weight: 607.95 g/mol
- CAS Number: 41672-81-5
- EINECS Number: 255-490-0
- Product Grade: Cosmetic Grade (Mainstream), High-End Cosmetic Grade (Luxury Brands), Industrial Grade (Daily Chemical Additives)
- Main Uses: Anti-aging active ingredients in cosmetics, medical aesthetic repair excipients, high-end daily chemical additives, biopharmaceutical intermediates
Physicochemical Properties of Dipalmitoyl Hydroxyproline
- Appearance and Odor: White to pale yellow powder or waxy solid, with no obvious odor or a slight characteristic lipid odor.
- Solubility: Insoluble in water, readily soluble in nonpolar solvents such as chloroform, ether, and petroleum ether; soluble in ethanol and propylene glycol (under heating conditions).
- Boiling Point: Decomposition temperature > 300℃ (no definite boiling point; acyl bond cleavage occurs at high temperatures).
- Melting Point: 62-66℃ (determined by differential scanning calorimetry, DSC peak temperature).
- pH Value (1% ethanol solution): 5.0-7.0 (neutral range, suitable for the pH environment of the skin surface).
- Activity indicators: In vitro experiments: Promotes collagen production rate of fibroblasts by 35%-50% (2.0% concentration).
- Other properties: Excellent compatibility with vitamin E, retinol, and hyaluronic acid, synergistically enhancing anti-aging effects; superior stability compared to monoacyl derivatives.
- Stability: Stable in pH range of 4.0-9.0; may undergo oxidative degradation upon contact with strong oxidants (such as peroxides).
Supplementary Technical Details for Dipalmitoyl Hydroxyproline
- Production Method: L-hydroxyproline and palmitoyl chloride undergo a diacylation reaction under an alkaline catalyst (such as triethylamine), followed by extraction, crystallization, and purification.
- Acute Toxicity (LD50): Oral LD50 in rats: >25000 mg/kg (practically non-toxic); Skin Irritation: Non-irritating (human patch test grade 0)
- Chronic Toxicity: High safety for long-term skin contact, complies with EU EC 1223/2009 cosmetics regulations, with no reports of sensitization or mutagenicity.
- Upstream and Downstream Products (Raw Materials): Upstream: L-hydroxyproline (pharmaceutical grade ≥99%), palmitoyl chloride (industrial grade ≥98%), triethylamine (reagent grade)
- Customs Code: 2933990090 (Other Heterocyclic Compounds)
- Main Impurities: Monopalmitoylhydroxyproline ≤1.0%, unreacted palmitoyl chloride ≤0.2%, heavy metals ≤0.5ppm
- Environmental Characteristics: Biodegradability ≥85% (OECD) Conforms to 301C standard, with no environmental accumulation, classifying it as a low-environmental-risk raw material.
- Shipping Method: Samples: Cold chain express (summer) / ambient temperature express (winter); Bulk: Temperature-controlled logistics (temperature ≤25℃)
- Payment Method: Samples: Payment in advance; Bulk: 50% deposit, balance due before shipment (negotiable for long-term cooperation)
- Certifications: ISO9001 Quality Management System Certification, GMP Cosmetic Production Standards, EU ECOCERT Natural Certification
- Technical Support: Provides formulation dissolution solutions, stability testing guidance, and efficacy verification data support (24-hour response)
Packaging and Storage of Dipalmitoyl Hydroxyproline
- Packaging: 100g/aluminum-plastic composite bag, 1kg/sealed aluminum can, 25kg/cardboard drum (lined with food-grade polyethylene film), customization available.
- Storage: Store in a cool, dry place (temperature ≤20℃, relative humidity ≤50%), sealed and protected from light, heat, and oxidants.
- Shelf Life: 24 months unopened; recommended to use within 3 months of opening (to prevent moisture absorption and clumping).
- CAS No.: 41672-81-5
- Molecular Formula: C37H69NO5
- Molecular Weight: 607.95 g/mol
- EINECS No.: 255-490-0
- Product Characteristics: Anti-aging and firming, promotes collagen synthesis, strengthens the skin barrier, high skin permeability, low irritation
- Usage Restrictions: Recommended addition amount in cosmetics: 0.5%-3.0% (excessive amounts may cause oily skin); must be used in combination with emulsifiers
- Precautions: Wear a dust mask during operation; heating and dissolving temperature ≤80℃ (avoid high-temperature decomposition); avoid storage with strong acids and alkalis
- After-sales Service: Provides COA analysis report, MSDS safety data sheet, and activity test report
Applications of Dipalmitoyl Hydroxyproline
- High-end cosmetic-grade Dipalmitoyl Hydroxyproline is a key ingredient in premium skincare products, added to anti-aging and firming creams, repair serums, and eye care products. It promotes collagen synthesis and improves skin elasticity.
- Medical-grade Dipalmitoyl Hydroxyproline can be used for post-medical aesthetic treatments, added to soothing creams and microneedling serums after light-based treatments. It helps strengthen the skin barrier and reduce redness and sensitivity.
- Cosmetic-grade Dipalmitoyl Hydroxyproline can be used in body care products, such as firming body lotions, neck creams, and hand creams. It effectively enhances skin elasticity and smooths fine lines around the eyes, lips, and neck.
- Daily-grade Dipalmitoyl Hydroxyproline can be used as an excipient in basic skincare products, enhancing their added value. It is also a raw material in affordable hair care products, helping to improve hair strength and shine.
- Daily-grade Dipalmitoyl Hydroxyproline can be used as an excipient in ordinary daily-use products, improving product compatibility, stability, and skin feel.
- Pharmaceutical-grade Dipalmitoyl Hydroxyproline can be used to prepare skin repair gels, ulcer treatment ointments, etc.; it is also a major component of postoperative repair patches and cold compresses.
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