Basic information of Dinoprostone
Basic information of Dinoprostone
CAS: 363-24-6
Formula：C20H32O5
Molecular Weight：352.46500
Synonym :
l-prostaglandine2
prostin
prostine2
7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid
(5Z,11A,13E,15S)-11,15-DIHYDROXY-9-OXO-PROSTA-5,13-DIEN-1OIC ACID
[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIEN-1-OIC ACID
[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIENOIC ACID
PROSTAGLANDIN
PROSTAGLANDIN E2
PROSTAGLANDINS E2
PGE2
(15s)-prostaglandine2
(5z,11-alpha,13e,15s)-11,15-dihydroxy-9-oxo-prosta-13-dien-1-oicacid
Physical and Chemical Properties of Dinoprostone
Appearance and properties: white crystalline powder.
Density: 1.148 g/cm3
Melting point: 66-68 °C
Boiling point: 530.071ºC at 760 mmHg
Flash point: 288.452ºC
Storage conditions: -20ºC
Vapor pressure: 0 mmHg at 25°C [1]
Formulations of Dinoprostone
Currently, injections, vaginal suppositories, and gels are available in the market.
Advantage of Dinoprostone
Unlike oxytocin, PGE2 has a mild uterine stimulating effect at all stages of pregnancy. Its uterine contraction is 10 to 40 times stronger than that of PGE2α. It has a transforming and dilating effect on the cervix and can be used to dilate the cervix before abortion. This is likely due to prostaglandins stimulating cervical fibroblasts, altering the alignment of collagen fibers.
Dinoprostone is available as an injection, vaginal suppository, and gel. The injection is administered intravenously. Both the vaginal suppository and gel are administered vaginally.
It has a stimulating effect on the uterus and is clinically used for induced labor, labor induction, and the treatment of postpartum hemorrhage.
Dinoprostone is a naturally occurring prostaglandin produced by the body that acts locally to promote contractions of uterine smooth muscle. Highassay provides synthetic prostaglandins that mimic the chemical structure of natural prostaglandins. However, we offer large quantities and competitive pricing. This allows for on-demand use based on clinical needs, extending its application range.
It is clinically used for inducing labor, inducing labor, and treating postpartum hemorrhage.
Non-sterile products have a one-week lead time.
We typically ship via express delivery, such as FedEx.
Highassay commercially produces dinoprostone on a regular basis and maintains inventory year-round.
We offer discounts for bulk purchases. Please contact us for specific discounts.
Specification of Dinoprostone
| Tests | Standards | Results |
| Appearance | White crystalline powder | Conforms |
| Identification | IR | Conforms |
| Water | 0.5%max | 0.23% |
| Residue on ignition | 0.5%max | 0.21% |
| Related substances | 15-epi-dinoprostone: 0.5%max 5,6-trans-dinoprostone: 0.5%max Any other impurity: 0.2%max | 0.35% 0.24% 0.07% |
| Assay | 97.0-103.0% | 99.21% |
