Basic Information of Benfotiamine
- Product Name: Benfotiamine
- English aliases: S-Benzoylthiamine O-monophosphate, Benzoylthiamine monophosphate, BTMP
- Industry Abbreviations: BF, BTMP
- Other language names: German: Benfotiamin; French: Benfotiamine; Spanish: Benfotiamina
- CAS number: 22457-89-2
- Molecular Formula: C₁₉H₂₃N₄O₆PS
- Molecular Weight: 466.45 g/mol
- Product Grade: Pharmaceutical grade, Food grade, Industrial grade, Cosmetic grade
- Main uses: Nutritional supplements, Food additives, Pharmaceutical intermediates, Cosmetic raw materials
Physicochemical Properties of Benfotiamine
- Appearance and smell: White to pale yellow crystalline powder, odorless or with a slight special odor.
- Solubility: Easily soluble in dilute acids, soluble in methanol and ethanol, slightly soluble in water, and insoluble in ether and chloroform.
- Boiling Point: Decomposition (gradually decomposes above 230℃)
- Melting Point: 176-180℃ (decomposes)
- Density: 1.42-1.46 g/cm³ (solid crystal density)
- Purity: ≥98% (Pharmaceutical Grade)
- Stability: Store in a cool, dry place where it is stable, avoiding high temperatures, humidity, and light.
- Danger: Low toxicity or practically non-toxic; some products may cause slight irritation.
- Emergency Response: Skin contact: Rinse immediately with plenty of water; Ingestion: Seek immediate medical attention.
Supplementary Technical Details for Benfotiamine
- Production Methods: It is prepared by phosphorylation and benzoylation of thiamine (vitamin B1), and high-purity product is obtained by chromatographic purification.
- Acute Toxicity (LD50): Oral LD50 in rats: >5000 mg/kg (practically non-toxic); Intraperitoneal LD50 in mice: 2000-2500 mg/kg
- Chronic Toxicity: Long-term use shows no significant cumulative toxicity and meets pharmaceutical-grade USP and EP standards.
- Upstream and downstream products (raw materials): Thiamine hydrochloride, phosphoric acid, benzoyl chloride, catalyst
- Upstream and downstream products (downstream): Diabetes adjunctive therapy drugs, vitamin B1 supplements, health foods, neuroprotective agents
- Quality Standards: Compliant with USP, EP, and GB (subject to adjustment based on product level).
- Detection Methods: HPLC, UV, IR, etc.
- Transportation Methods: Sea freight, air freight, and express delivery
- Payment Methods: T/T, L/C, Western Union, etc.
- Certification Status: ISO9001, GMP, kosher halal etc.
- Technical Support: Provide product application technical guidance and solutions
Packaging and Storage of Benfotiamine
- Packaging: 25kg/fiber drum (lined with polyethylene bag), or according to customer requirements
- Storage: Store in a cool, dry, and well-ventilated warehouse; avoid direct sunlight and moisture
- Shelf Life: 24 months from the production date under proper storage conditions
- CAS number: 22457-89-2
- Molecular Formula: C₁₉H₂₃N₄O₆PS
- Molecular Weight: 466.45 g/mol
- Implementation Standards: Enterprise standards or USP/BP/EP/CP
- Precautions: Avoid storing with strong oxidizers, strong acids, or strong alkalis; wear protective equipment during operation.
- After-sales Service: Provides COA and MSDS; free returns and exchanges for quality issues; technical support.
Applications of Benfotiamine
Pharmaceutical Field
- Pharmaceutical-grade Benfotiamine can be used in the production of tablets or granules.Used to treat conditions such as diabetic peripheral neuropathy, chronic metabolic diseases, and vitamin B1 deficiency.The typical medicinal dosage of Benfotiamine is 300-600 mg per day.
- Pharmaceutical-grade Benfotiamine can also be used in the exploration of treatments for certain other specific diseases.For example, protection against chemotherapy-induced neurotoxicity, migraine prevention, etc.
Food Sector
- Food-grade Benfotiamine can be used in the production of dietary supplements.As a highly effective vitamin B1 supplement, its bioavailability is far superior to that of ordinary vitamin B1.It helps the body increase the rate of energy metabolism, maintain nerve and heart health, and prevent problems such as beriberi, loss of appetite, and indigestion caused by deficiencies.
- Food-gradeBenfotiamine can be used as a nutritional fortifying ingredient in specific formulated foods.It is especially suitable for patients who may have vitamin B1 absorption problems (such as the elderly and those with digestive system diseases).
Cosmetics Industry
- Cosmetic-grade Benfotiamine is a core ingredient in high-end and mid-range anti-aging, anti-glycation, and repairing skincare products.Benfotiamine is highly lipophilic, easily penetrates the skin barrier, and has a high safety profile.Suitable for all skin types, it effectively improves skin aging and dullness.
- Cosmetic-gradeBenfotiamine can be used as a supplementary nutrient in hair and scalp care products.On the one hand, it improves the metabolic capacity of hair follicles, and on the other hand, it protects hair follicles from oxidative stress damage.
Other fields
- Feed-grade Benfotiamine is primarily used in high-end pet nutrition (such as neurological support formulas for dogs and cats) or in the breeding of economically valuable specialty animals (such as ornamental fish and rare birds).This is beneficial for improving survival rate and stress resistance, etc.
- Industrial-grade Benfotiamine can be used as a raw material for further purification and processing.
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