Basic Information of Minoxidil
- Product Name: Minoxidil
- Chemical Name: 6-(1-Piperidinyl)-2,4-diaminopyrimidine 3-oxide
- IUPAC Name: 2,4-Diamino-6-piperidin-1-ylpyrimidine 3-oxide
- CAS No.: 38304-91-5
- EINECS No.:253-874-2
- Molecular Formula: C₉H₁₅N₅O
- Molecular Weight: 209.25 g/mol
- Appearance: White to off-white crystalline powder
Applications of Minoxidil
Minoxidil Tablets：Used for the treatment of resistant hypertension, it is considered only when standard antihypertensive medications prove ineffective, due to its significant side effects.
Topical Minoxidil Preparations：It is the first drug globally to receive FDA approval for the treatment of androgenic alopecia.
Other Applications: Used in pharmaceutical R&D, the synthesis of other compounds, or as a reference standard.
Why choose Highassay?
Highassay is a China-based supplier of Minoxidil(CAS: 38304-91-5). We provide both industrial-grade and pharmaceutical-grade Minoxidil raw materials.
Our minoxidil API has high purity (≥99%) and good solubility.In addition to being used to produce antihypertensive medications, it is also suitable for the preparation of topical medications for treating hair loss.
Our products meet with GMP standards, and our production processes are well-established, ensuring a stable supply capacity.Although the usage of minoxidil in the field of hypertension is limited, its progress in the treatment of hair loss has been positive.By choosing us, you not only meet your current large-scale production needs for topical formulations but also secure a supply of high-quality raw materials to support your future strategic expansion into oral formulations (for hair loss treatment).
Provided with the shipment: COA, MSDS, impurity profile analysis, stability data, etc.
For bulk purchases of Minoxidil raw materials, choose Highassay.
Minoxidil : Packaging and MOQ
We generally offer two standard packaging options:
- Small Quantities: Approximately 1 kg.We typically use aluminum foil bags, suitable for R&D testing, process validation, and sample orders.
- Large Quantities: 25 kg. The product is packaged in an inner plastic bag enclosed within an outer cardboarddrum; this option is primarily used for commercial-scale mass production.
We offer a flexible ordering policy:
- Standard Orders: 1 kg
- Sample Orders: Negotiable(gram-scale quantities),available for scientific research or early-stage R&D clients. Please contact our customer service team for inquiries.
Information Overview
- Specification of Minoxidil
- Physicochemical Properties of Minoxidil
- Minoxidil vs. Finasteride
| Item | Standard | Test Method |
| Purity | ≥99% | HPLC |
| Single Impurity | ≤0.5% | HPLC |
| Total Impurities | ≤1.0% | HPLC |
| Loss on Drying | ≤0.5% | 105℃Constant-Temperature Drying Method |
| Heavy Metals | ≤10 ppm | Atomic Absorption Method |
| Residual Solvents | Meet ICH Q3C | GC |
| Microbial Limits | Compliant with USP/EP | Pharmacopoeia Method |
| Standards Complied | USP/EP/CP/GMP | Pharmacopoeia Standards |
| Item | Details |
| Melting Point | ~258–261 °C (decomposition) |
| Solubility | Slightly soluble in water, ethanol, methanol; practically insoluble in ether, chloroform; soluble in DMSO |
| LogP (XlogP) | 0.8 |
| TPSA | 89.9 Ų |
| Stability | Sensitive to light, heat, and humidity; stable under neutral/weakly acidic conditions |
| Storage Conditions | Sealed, dry, cool place, protect from light (room temperature storage is acceptable for API; long-term storage recommended at 2–8°C) |
| Item | Standard | Test Method |
| Purity | ≥99% | HPLC |
| Single Impurity | ≤0.5% | HPLC |
| Total Impurities | ≤1.0% | HPLC |
| Loss on Drying | ≤0.5% | 105℃Constant-Temperature Drying Method |
| Heavy Metals | ≤10 ppm | Atomic Absorption Method |
| Residual Solvents | Meet ICH Q3C | GC |
| Microbial Limits | Compliant with USP/EP | Pharmacopoeia Method |
| Standards Complied | USP/EP/CP/GMP | Pharmacopoeia Standards |
Overall, the purification of industrial-grade Minoxidil presents a moderate level of difficulty and entails significant costs; consequently, utilizing pharmaceutical-grade material directly for veterinary applications proves to be more cost-effective, fully compliant, and lower-risk.
Liquid Minoxidil (Minoxidil tincture, Minoxidil lotion, Minoxidil spray)
Foam Minoxidil
Gel Minoxidil
2% (Suitable for use by women and children)
5% (Standard concentration for men)
5% Usage for Women (Once daily; do not exceed 1 ml per application)
Indications for Minoxidil: Androgenetic alopecia (seborrheic alopecia), alopecia areata, or other types of hair loss (e.g., adjunctive treatment for postpartum hair loss, supportive care during the recovery phase following chemotherapy-induced hair loss, and traction alopecia).
Whether Minoxidil is safe depends on your method of use and your individual physical condition.
Topical formulations are safe, over-the-counter medications with a low risk profile; potential side effects are primarily limited to localized scalp reactions.
Oral tablets are prescription medications that require strict monitoring and must be used under the guidance of a physician.
Minoxidil: Definition and Mechanism of Action
What is Minoxidil?
Minoxidil is a topical preparation primarily used to treat androgenic alopecia (AGA), and is also widely utilized for other types of hair loss, such as alopecia areata.Originally developed as an antihypertensive drug, it was successfully repurposed as a hair-growth medication after exhibiting the side effect of “excessive hair growth.”
The Mechanism of Action of Minoxidil
Minoxidil works by dilating blood vessels in the scalp,increase blood supply,helps activate hair follicles and prolong the hair growth cycle.At the same time, it can inhibit the effects of male hormones on hair follicles.
Minoxidil: Technical Grade vs Pharmaceutical Grade Comparison
| Comparison Item | Technical Grade | Pharmaceutical Grade |
| Purity Requirement | 98%–99% | ≥99.0% (compliant with pharmacopoeia standards) |
| Executive Standard | Enterprise Standard | National Pharmacopoeia Standard (CP/USP/EP) |
| Impurity Control | Routine chemical quality control, no limit for single impurity | Strictly monitored, single impurity ≤0.2%, total impurities ≤0.5% |
| Residual Solvents | No strict regulation | Itemized control (methanol, ethanol, dichloromethane, piperidine, etc.) |
| Residue on Ignition | No explicit requirement | ≤0.15% |
| Loss on Drying | No explicit requirement | ≤0.5% |
| GMP Compliance | Not required | Must comply with GMP standards |
| Regulatory Filing | No DMF filing required | Supports DMF filing and ANDA submission |
| Main Applications | Research intermediates, process development, veterinary drug raw materials (requires further purification) | API for human pharmaceutical preparations |
| Downstream Products | Laboratory research, reference standard preparation | Minoxidil tablets, topical solution, foam, gel |
| Target Customers | R&D institutions, chemical factories, veterinary drug factories | Pharmaceutical enterprises, preparation manufacturers |
