Basic Information on Chlorogenic Acid
- Product Name: Chlorogenic Acid
- Synonyms: Caffeotannic Acid
- CAS No.: 327-97-9
- Molecular Formula: C₁₆H₁₈O₉
- Molecular Weight: 354.31 g/mol
- Structure: OC1C(CC(CC1O)(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O
What is Chlorogenic Acid?
Chlorogenic Acid is a safe, mild, and natural compound.It is primarily derived from extracts of Eucommia leaves, honeysuckle, coffee, or other plants.It can also be obtained through chemical synthesis.The preparation process of Chlorogenic Acid in industry is mature, but the cost of industrial synthesis is much higher than that of plant extraction and it produces more byproducts.Therefore, plant-derived Chlorogenic acid is currently the dominant source in the market.
Chlorogenic Acid possesses potent antioxidant and antimicrobial properties and is utilized in fields such as health supplements, skincare and cosmetics, and food products.
Why Choose Highassay?
Highassay is a trading intermediary with 15 years of industry experience.We maintain partnerships with multiple source factories for Chlorogenic Acid, ensuring direct supply and significant price advantages.Choosing us, you can eliminate a range of concerns—including supply instability, significant quality variations, and supplier management.
Every shipment includes a full set of technical documents (COA, MSDS, TDS), to help you achieve rapid mass production.
You may contact customer service to request a free sample before purchasing.Regarding Chlorogenic Acid pricing,click below to let us know your chlorogenic acid needs, and we will send you our latest price quote for chlorogenic acid powder within 24 hours.
For bulk purchases of Chlorogenic Acid, Highassay is an excellent choice.
Highassay’s Chlorogenic Acid
Highassay is a Chlorogenic acid powder supplier based in China, offering Chlorogenic acid powder derived from two distinct sources.
- One type is derived from plant extraction, available in multiple purity grades (25%–98%). It appears as a powder ranging in color from brownish-yellow to tan or dark brown; it is prone to oxidation, and its color deepens as storage time increases.
- Another method is chemical synthesis, yielding a high-purity product (≥95%) that appears as a white to pale yellow or beige crystalline powder; the higher the purity, the closer the color is to white, and the more stable the color remains.
Chlorogenic Acid: Packaging and Storage
Highassay offers many packaging options to ensure maximum convenience for your production processes. Customization is also available upon request.
- Standard Commercial Packaging: 25 kg/drum, lined with a PE bag and a light-shielding aluminum foil vacuum bag.
- External Drum Label: Contains information such as Chlorogenic Acid Powder, CAS Number, Purity, Batch Number, Production Date, Shelf Life, etc.
- Shelf Life: 24 months (in original, unopened packaging).
- Storage: Store in a cool, dry place, away from light.
Highassay Chlorogenic Acid Supplements | Your Raw Material Solution
Our Chlorogenic acid raw materials can be used to manufacture many supplements. For your Chlorogenic acid needs, choose Highassay.
- Filled with high-purity chlorogenic acid pure powder; features precise dosage and rapid absorption.
- Recommended Purity: ≥98%
- Suggested Dosage: 300–500 mg per capsule
- Key Selling Points: Focuses on potent antioxidant effects, blood sugar support, weight management, and vascular health.
- Can be formulated in combination with various plant-derived ingredients, such as flavonoids, Vitamin C, anthocyanins, etc.
- Recommended Purity: 25%–80%
- Suggested Dosage: 150–300 mg/tablet
- Key Selling Points: Herbal Wellness & Daily Conditioning; Anti-Aging & Skin Brightening
- Liquid dosage form: Easily absorbed, gentle on the stomach and intestines; suitable for middle-aged and elderly individuals, as well as those with sensitive digestive systems.
- Recommended Purity: 25%–50%
- Suggested Dosage: 50–200 mg/bottle (10–50 mL)
- Technical Considerations: Requires pH and sweetness adjustment, and the addition of antioxidants.
- Chlorogenic Acid + Coffee Polyphenols: A Viral Bestseller (Capsule Form)
- Recommended Purity: 10%–50% (Chlorogenic Acid Content)
- Suggested Dosage: 200–400 mg Chlorogenic Acid per capsule
- Key Selling Points: Blocks sugar absorption and supports weight management; promotes healthy blood sugar metabolism; helps maintain healthy post-meal blood sugar and insulin levels.
Dosage Form | Common Problems | Solutions |
| Pure Powder Capsules | Poor powder fluidity and large filling weight variation | Add glidants such as microcrystalline cellulose and magnesium stearate |
| Tablets | Tablet sticking and slow disintegration | Control moisture content, select appropriate fillers and disintegrants |
| Oral Liquid | Chlorogenic acid degradation and deepening color change | Adopt light-proof packaging, adjust pH value to 3.5-4.5, add antioxidants (e.g. VC, EDTA) |
- Anti-inflammatory and Soothing;
- Antibacterial and Antiviral;
- Repairs the skin;
- Antioxidant, free radical scavenging.
The main advantage of synthetic Chlorogenic acid is that it solves the fat solubility issue inherent in natural Chlorogenic acid.Complements natural Chlorogenic acid, expanding its scope of application.
Beverages (coffee and tea), fruits (apples and pears), vegetables (tomatoes and lettuce), and other sources (Eucommia leaves and sunflower seeds).
Coffee is the highest dietary source of Chlorogenic acid among daily beverages, with significantly higher levels of Chlorogenic acid in coffee compared to Chlorogenic acid in tea.
No; when taken orally at appropriate doses, it is safe. But if you excessive intake or intravenous administration may carry some potential risks.
Within the human intestinal tract, Chlorogenic acid undergoes hydrolysis and metabolism, breaking down into caffeic acid and quinic acid; thus, Caffeic acid is the primary metabolite of Chlorogenic acid.
Applications of Chlorogenic Acid
Chlorogenic Acid in Cosmetics
It can be incorporated as a commonly used core ingredient in skincare and personal care products.Residue-type: ≤0.005%; Rinse-type: ≤0.01%.Chlorogenic Acid is a natural polyphenol component that offers gentle, soothing, and antioxidant effects.
Chlorogenic Acid in Food
Chlorogenic acid is an antioxidant and antimicrobial ingredient for food products.It can be added to products (beverages/teas, meat products/braised foods, and baked goods/confectionery).It is a functional health food additive, with an inclusion level of ≤0.5 g/kg (0.05%).
Chlorogenic acid can be added to the feed of animals such as pigs, chickens, and aquatic animals as a green, antibiotic-free feed additive.It helps promote animal growth and enhance immunity.
Chlorogenic acid in Pharmaceuticals and Healthcare
Chlorogenic acid can be utilized in proprietary Chinese medicines, as well as in pharmaceutical preparations for cardiovascular and cerebrovascular conditions, hepatobiliary disorders, and anti-inflammatory purposes.It possesses properties that clear heat and detoxify, lower blood sugar and lipids, and protect the liver and blood vessels.
Chlorogenic acid,as a key ingredient in the production of chlorogenic acid nutritional supplements.To meet the needs of different market positioning and consumer groups.
Natural Chlorogenic Acid vs. Industrial Chlorogenic Acid
| Comparison Item | Natural Plant-Extracted Chlorogenic Acid | Industrially Chemically Synthesized Chlorogenic Acid |
| Appearance & Color | Yellowish-brown to tan powder | White / off-white crystalline powder |
| Purity Range | 25%～98%, with relatively abundant impurities | 98%～99.5%, high-purity single component |
| Impurity Composition | Contains natural plant flavonoids, polysaccharides and pigment impurities | Minimal pigment impurities, structurally pure & single component |
| Water Solubility | Moderate solubility, solution prone to slight turbidity | Excellent water solubility, crystal clear aqueous solution |
| Light & Thermal Stability | Prone to oxidative discoloration; darkens over long-term storage | High structural stability, resistant to discoloration and moisture absorption |
| Market Price | Low production cost, high cost performance | Relatively high price, about twice that of natural chlorogenic acid |
| Primary Applications | Dietary supplements, feed additives, conventional antioxidant cosmetics | Pharmaceutical API, reference standards, high-end skincare products, high-standard export preparations |
| Label Claim | Eligible to be marked as plant-derived & natural chlorogenic acid | Cannot be claimed as natural; only registered as chemical raw material |
| Shelf Life | Relatively short, easy to agglomerate and deteriorate | Longer shelf life, more stable storage performance |
Overview of Chlorogenic Acid Industry Grades
| Grade | Conventional Purity | Appearance | Core Control Standards | Applicable Fields |
| Pharmaceutical Grade (Pharmacopoeia Grade) | HPLC ≥ 98.5% | White / Off-white | Compliant with pharmacopoeia standards, ultra-low heavy metals, strict control of single impurities, sterile, no solvent residue, qualified optical rotation | Injection preparations, pharmaceutical API, medicinal capsules, drug reference substances |
| Health Food Grade | 50%～98% | Yellowish-brown / Light yellow | Compliant with China GB food safety standards, qualified pesticide residues and microorganisms, safe for oral administration | Dietary supplements, oral capsules, pressed candies, health-care oral liquids |
| Cosmetic Grade | 25%～98% | Yellowish-brown / Tan | Strict control of irritant impurities, ultra-low lead & arsenic heavy metals, stable anti-corrosion, non-sensitizing, good skin compatibility | Repair essences, soothing creams, anti-acne skincare, anti-aging & brightening cosmetics |
| Food Grade | 5%～50% | Dark yellowish-brown | Compliant with national food additive standards, broad-spectrum bacteriostasis, cost-effective | Beverages, baked goods, natural fresh-keeping, food antioxidant & preservative applications |
| Feed Grade | 5%～20% | Dark brown | Compliant with animal husbandry safety standards, priority on cost performance | Livestock & poultry breeding, bacteriostatic and growth-promoting feed additives |
Physicochemical Properties of Chlorogenic Acid (Based on Plant Extracts)
- Appearance:Brown-yellow to brown powder
- Odor:Faint, characteristic odor; bitter taste
- Solubility:Easily soluble in hot water, methanol, and ethanol; slightly soluble in cold water; insoluble in petroleum ether and diethyl ether
- Stability:Prone to oxidation and discoloration upon exposure to light, high temperatures, or humidity; color gradually deepens over time
- Melting Point: 208–210°C
- Hygroscopicity:Easily absorbs moisture and tends to cake
- Dissociation Constant & pH: pKa ≈ 33 (carboxyl group); aqueous solutions are weakly acidic (pH of a 1% aqueous solution is approximately 4.5–5.5)
- Optical Activity:Naturally optically active; [α] = -35.0° to -38.0° (c=1, H₂O)
- Safety: Safe and non-toxic substance
- Shelf Life:24 months (when stored in a sealed container under cool, dry conditions)
