Basic Information of 5-Bromophthalide
- Product Name: 5-Bromophthalide
- Synonyms: 5-Bromo-1(3H)-isobenzofuranone, 5-Bromo-3H-isobenzofuran-1-one
- CAS No.: 64169-34-2
- EINECS No.: 613-485-4
- Molecular Formula: C₈H₅BrO₂
- Molecular Weight: 213.03
What is 5-Bromophthalide?
- 5-Bromophthalide, also known as 5-Bromoisobenzofuran-1(3H)-one, CAS No. 64169-34-2, is a brominated derivative of phthalide.
- 5-Bromophthalide possesses excellent reactivity (attributable to the modifiability of the bromine atom at the 5-position and the lactone ring) and structural stability (derived from the rigid fused-ring aromatic system of the phthalide core).It serves as an intermediate and is used in fields such as pharmaceuticals, chemicals, and pesticides.
- It is stable at ambient temperatures and easy to store and transport. Furthermore, it is free from special hazardous material restrictions, allowing for safe and rapid delivery via sea, air, or land transport.
Why choose Highassay?
Highassay is a China-based supplier of 5-bromophthalide raw materials. We provide you with industrial-grade, pharmaceutical-grade, and reagent-grade 5-bromophthalide powder.It is an ideal choice for groups such as citalopram API manufacturers and pesticide intermediate buyers.
Quality Assured, Complete Documentation
Our production of 5-bromophthalide raw materials complies with ISO 9001 and GMP standards. Shipments are accompanied by a Certificate of Analysis (COA), Safety Data Sheet (SDS), Technical Data Sheet (TDS), Certificate of Origin (COO), impurity profile, and stability data. If you require other additional documentation, please contact us, and we will provide them.
Mature Process, Stable Batches
Highassay possesses a mature 5-Bromophthalide synthesis route and comprehensive manufacturing facilities for 5-bromophthalide, ensuring batch-to-batch consistency in our 5-bromophthalide powder. Particularly suitable for meeting the stringent requirements of pharmaceutical-grade customers regarding impurity control and purity.
Professional Selection Advice and Customization Services
Different grades of 5-Bromophthalide come with different specifications for purity, particle size, and impurity content. If you are looking to make a purchase for high purity 5-Bromophthalide or need 5-Bromophthalide 98%,please kindly inform us of your industry sector and intended application. Our team will subsequently offer expert guidance and customized packaging for 5-Bromophthalide.
Bulk purchases of 5-bromophthalide, choose Highassay.
Click below to receive free samples and the latest 5-Bromophthalide price quotes.
Packaging for 5-Bromophthalide
Highassay offers small-format packaging in aluminum foil bags (500g, 1kg, 2kg).
Our standard packaging consists of fiber drums lined with double-layer PE bags (25kg).
For 5-bromophthalide powder requiring higher purity standards, we provide protective packaging inerting gas protection packaging is available to safeguard against oxidation and exposure to moisture., thereby ensuring the stability of the high-purity raw material.
Need a different packaging solution to streamline your daily production? Just let us know — we’re always ready to make adjustments.
Grade and Applications of 5-Bromophthalide
The purity of our 5-bromophthalide has been verified via HPLC/GC analysis and meets established standards. If you are seeking a supplier of 5-bromophthalide offering high purity, stable supply, and comprehensive documentation, Highassay will be your reliable long-term partner.
- Specifications for our pharmaceutical-grade 5-bromophthalide: Purity ≥ 98%, Single Impurity ≤ 0.5%, Total Impurities ≤ 1–2%, Moisture ≤ 0.5%. Other specifications can be customized according to client requirements.
- As an intermediate for Citalopram and an Escitalopram API, pharmaceutical-grade 5-bromophthalide can also be suitable for synthesizing active compounds, including psychotropic, anti-inflammatory, anti-tumor, and antiviral agents.
- Highassay supplies industrial-grade 5-bromophthalide with a purity of ≥97.0% (GC/HPLC) and a moisture content of ≤1.0%, with no specific requirements regarding other impurities.
- Industrial-grade 5-bromophthalide can be utilized in the structural modification of highly effective, low-toxicity pesticides, fungicides, and herbicides, delivering both improved efficacy and a lower environmental footprint.
- Industrial-grade 5-bromophthalide is also applicable in the synthesis of benzofuranones, isoindoles, and phthaloyl derivatives.
- Specifications for our High-Purity Grade 5-Bromophthalide: Purity ≥ 99.5%–99.9%, Single Impurity ≤ 0.05%, and Metal Ion Content Controlled at the ppb Level.
- High-Purity Grade 5-Bromophthalide is utilized in the fields of optoelectronic materials (OLEDsand Liquid Crystal Display materials) and electronic chemicals (specifically in the manufacturing processes for semiconductors and electronic components).
Specifications of 5-Bromophthalide
- Specifications of 5-Bromophthalide
| Test Item | Industrial Grade | Pharmaceutical Grade | High Purity Grade |
|---|---|---|---|
| Appearance | Beige to light yellow crystalline powder | White to off-white crystalline powder | White crystalline powder |
| Purity (HPLC/GC) | ≥97.0% | ≥98.5% | ≥99.5% |
| Maximum Single Impurity | ≤1.0% | ≤0.1% | ≤0.05% |
| Maximum Total Impurities | ≤2.0% | ≤1.0% | ≤0.1% |
| Moisture | ≤1.0% | ≤0.5% | ≤0.3% |
| Melting Point | 161–168 ℃ | 162–166 ℃ | 163–166 ℃ |
| Heavy Metals | — | ≤10 ppm | ≤1 ppm |
| Metal Ions | — | — | Controlled at ppb level |
| Residual Solvents | No mandatory requirement | Complies with Pharmacopoeia / Customer requirements | Complies with electronic grade requirements |
| Application | Pesticides, general fine chemicals | Citalopram / Escitalopram API, pharmaceutical intermediates | OLED, optoelectronic materials, electronic chemicals |
| Packaging | 25kg fiber drum | Inert gas protected packaging | Inert gas protected + light-proof packaging |
Store under inert gas (argon or nitrogen) at room temperature, protected from moisture. Shelf life is 2 years in sealed original packaging.
You can buy 5-Bromophthalide from Highassay.
Highassay is a trusted 5-Bromophthalide supplier offering pharmaceutical grade, industrial grade, and high-purity grade (≥99.5%). Contact us for a quote.
And we offer you free samples for your testing.
Pharmaceutical grade has purity ≥98% with strict impurity control (single impurity ≤0.5%), suitable for API synthesis. Industrial grade has purity ≥97% with no specific impurity requirements, suitable for pesticides and fine chemicals.
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Physicochemical Properties of 5-Bromophthalide
- Appearance: Beige to light yellow crystalline powder
- Chemical Structure: Contains a phthalide ring structure (a benzene ring fused with a five-membered lactone ring)
- Structural Features: The 5-position of the phthalide backbone is substituted by a bromine atom
- Compound Class: Phthalide derivative; belongs to the class of lactone compounds
- Melting Point: 162–166 °C
- Boiling Point: 377.7 ± 0 °C (760 mmHg)
- Flash Point: 182.2 ± 9 °C
- Density: 1.742 ± 06 g/cm³
- Refractive Index: 1.625
- Vapor Pressure: 0.0 ± 9 mmHg (25 °C)
- LogP: 1.74
- tPSA: 26.3 Ų
- Solubility: Soluble in organic solvents such as acetone, ethyl acetate, DCM, and THF; slightly soluble in water and alcohols
- Stability: Stable at room temperature; susceptible to ring-opening hydrolysis in the presence of strong acids or strong bases
- Storage: Store under an inert gas atmosphere at room temperature; avoid moisture
- Shelf Life: 2 years (when kept in sealed original packaging)
