Basic Information of 4-Amino-1,2,4-Triazole
- Product Name: 4-Amino-1,2,4-triazole (4-ATZ)
- Synonyms: 4-Amino-1,2,4-triazole, 1,2,4-Triazole-4-amine、4-ATZ
- Molecular Formula: C2H4N4
- Molecular Weight: 84.08
- CAS No.: 584-13-4
What is 4-Amino-1,2,4-Triazole？
4-Amino-1,2,4-Triazole (CAS No.: 584-13-4) is a five-membered aromatic heterocycle containing two carbon atoms, three nitrogen atoms, and an amino group at the 4-position. Possessing both strong hydrogen-bonding and metal-coordination capabilities, as well as facile multi-site modifiability, it demonstrates excellent drug-like properties and significant application potential across the fields of pharmaceutical, agricultural, and materials sectors.
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Why choose Highassay?
As a major pharmaceutical intermediate, Highassay is a professional 4-Amino-1,2,4-Triazole supplier from China.
We offer 3 different 4-Amino-1,2,4-Triazole grades raw material.
For bulk purchases of 4-Amino-1,2,4-Triazole, please choose Highassay.
Pharmaceutical-grade 4-Amino-1,2,4-TriazolePharmaceutical-grade 4-Amino-1,2,4-Triazole with a purity of ≥ 99.0% (HPLC), moisture content ≤ 0.5%, individual impurities < 0.1%, and total impurities < 0.5%, GMP-compliant.
Industrial-grade 4-Amino-1,2,4-TriazoleIndustrial-grade 4-Amino-1,2,4-Triazole features a purity of ≥98%, with trace amounts of isomers, moisture, and inorganic salts permitted; it offers high batch-to-batch consistency and a competitive price advantage.
High-purity 4-Amino-1,2,4-TriazoleHigh-purity 4-Amino-1,2,4-Triazole features a purity of ≥99.5%, the total impurity level is extremely low (at the ppb level); its purity is guaranteed, and flexible packaging options are available.
Physicochemical Properties of 4-Amino-1,2,4-Triazole
- Appearance: White to off-white crystalline powder.
- Melting Point: 84–86°C (slight variations may occur depending on crystal form or purity).
- Solubility: Readily soluble in water (a key characteristic), ethanol, and methanol; slightly soluble in non-polar organic solvents such as diethyl ether and acetone.
- Stability: Stable under normal temperature and pressure, but sensitive to light and heat (should be stored in a light-protected, sealed container for long-term storage).
4-Amino-1,2,4-Triazole (4-ATZ) vs. 3-Amino-1,2,4-Triazole (3-ATZ)
- The position of the amino group differs (in 3-ATZ, the amino group is attached to a ring carbon). Consequently, they differ significantly in terms of their electronic properties, coordination modes, biological activity, and other aspects.So,know the difference between 4-ATZ and 3-ATZ is important.
- In 4-ATZ, the amino group is attached to a ring nitrogen; Therefore, it is more basic and has a more unique coordination ability, and is often used in drug synthesis requiring specific pharmacophore orientation.
What is 4-Amino-1,2,4-Triazole used for?
What makes 4-Amino-1,2,4-triazole (4-ATZ) so versatile? Its unique N-linked amino group and triazole ring structure. Let’s take a look together at the fields in which it is used.
Used in the production of antifungal drugs (such as Fluconazole), as well as antiviral and anticancer medications; Italso as enzyme inhibitors (specifically, catalase inhibitors) in biological research.A key 4-Amino-1,2,4-triazole pharmaceutical intermediate.
These constitute the core pharmacophore of triazole-based agrochemicals,likeherbicides, fungicides, and plant growth regulators. A trusted 4-Amino-1,2,4-Triazole for triazole fungicide synthesis.
Capable of forming a protective adsorbed film on steel, copper, copper alloys, and circulating water systems under acidic and neutral conditions, thereby preventing corrosion. An effective 4-Amino-1,2,4-Triazole corrosion inhibitor for copper alloys.
Used as raw materials for high-nitrogen heterocycles, for the preparation and improvement of insensitive explosives, propellants, and pyrotechnic materials. A valuable 4-Amino-1,2,4-Triazole energetic material precursor.
Multifunctional bridging organic ligands for MOFs, COFs, coordination polymers, fluorescent materials, and similar substances.A premium 4-Amino-1,2,4-Triazole ligand for MOF synthesis.
Comparative Advantages vs. Similar Triazole Intermediates
- Comparative Advantages vs. Similar Triazole Intermediates
| Triazole Intermediate | Amino Position | Coordination Ability | Cost Advantage | Main Application Scope |
| 4-Amino-1,2,4-Triazole (4-ATZ) | Ring Nitrogen | Strong (directional) | High (mass production) | Pharma, MOF, corrosion inhibition |
| 3-Amino-1,2,4-Triazole (3-ATZ) | Ring Carbon | Moderate | Medium | Agrochemicals, general synthesis |
| 1-Amino-1,2,4-Triazole | N1 Position | Weak | Low | Basic organic synthesis |
| 5-Amino-1,2,4-Triazole | Ring Carbon | Moderate | Medium | Agrochemicals, dyes |
No.The relationship between the two is that of a parent entity(1,2,4-Triazole) and a derivative(4-Amino-1,2,4-Triazole).
At room temperature, 4-Amino-1,2,4-triazole exhibits a water solubility of approximately 810 g/L, belongs to an extremely water-soluble compound.
Yes. We provide a COA with each shipment, including purity, moisture, impurity profile, and other quality parameters.
Yes. As a non-hazardous material, it can be shipped by air, sea, or land under standard conditions. No special temperature control (e.g., dry ice) is required.
Safety, Storage, and Transport of 4-Amino-1,2,4-Triazole
Safety Information:
4-Amino-1,2,4-Triazole is irritating to the eyes, respiratory system, and skin. During handling, protective eyewear, a face mask, and rubber gloves must be worn.
GHS Hazard Statements: H315 (Skin irritation), H319 (Serious eye irritation), H335 (May cause respiratory irritation).
Packaging:
We offer standard packaging options: 25 kg/drum (Pharmaceutical Grade), 500 kg/bag (Industrial Grade), and 1 kg/5 kg (High-Purity Grade for R&D).
Storage:
For short-term storage, keep at 15–30°C in a dry place, away from light. For long-term storage (>6 months), refrigerate at 2–8°C .This helps maintain its stability.
Transport:
4-Amino-1,2,4-Triazole is not classified as a hazardous material; it may be transported at ambient temperature using standard chemical shipping methods.
Do not transport together with Oxidizers/Acids
