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Basic information of Sirolimus

Product Name: Sirolimus
English Aliases: Rapamycin, AY-22989, RAPAMUNE
Industry Abbreviation: SRL, RAP
CAS No.: 53123-88-9
Molecular Formula: C51H79NO13
Molecular Weight: 914.172
Product Category: Immunosuppressant, Antibiotic
Main Uses: Organ transplant rejection treatment, tumor therapy, rare disease treatment

Sirolimus is a novel macrolide immunosuppressant.It also has a more well-known name—R
Highassay is a supplier of Sirolimus raw materials from China.Our raw materials are of top quality, competitively priced, and come with excellent after-sales service.For more information, please contact Highassay for a quote.

Appearance: White to off-white crystalline powder, odorless.
Solubility: Soluble in organic solvents such as methanol, ethanol, acetone, and chloroform; very slightly soluble in water; almost insoluble in ether.
Production Method: Microbial fermentation extraction and purification process.
Toxicity Data: Oral LD50 in rats > 2000 mg/kg.
Storage: Preserve in tight, light-resistant containers. Store at room temperature.
Packaging: 1 kg/can, or customized according to customer requirements.

Sirolimus active pharmaceutical ingredient can be used to make various finished formulations: oral liquids, tablets, gels.
Sirolimus oral solution: a pale yellow or yellow clear oily viscous liquid, which facilitates dosage adjustment.
Sirolimus tablets: For example, they are white triangular (1 mg) or light yellow triangular (2 mg) for easy carrying and administration.Tablets produced by different manufacturers may have different shapes and colors.
Sirolimus is a potent drug, so its side effects need to be closely monitored during use.
Common side effects of sirolimus include: high cholesterol/high blood lipids, oral ulcers, peripheral edema, thrombocytopenia, and delayed wound healing.

Sirolimus and tacrolimus are both immunosuppressants used in organ transplantation.However, they are different in their mechanisms of action.
Tacrolimus preparations inhibit calcineurin, which can prevent the generation of activation signals for immune cells at the source.
Sirolimus works by inhibiting mTOR, which blocks immune cell proliferation signals and thus achieves immunosuppression.
Generally, doctors will select and adjust medications based on the patient’s specific condition.Tacrolimus is the most potent drug, but it is also nephrotoxic.Sirolimus has no nephrotoxicity and is the preferred preparation to protect kidney function from damage.

Sirolimus is a pharmaceutical intermediate for everolimus.Everolimus is based on sirolimus with minor modifications to its chemical structure.This makes everolimus superior to sirolimus in terms of oral absorption quotient.
Sirolimus is primarily used for immunosuppressive therapy after organ transplantation.(To prevent rejection after kidney transplantation, it is usually used in combination with drugs such as cyclosporine and corticosteroids.).Sirolimus cannot be used in liver or lung transplant recipients.
Sirolimus can be used as a therapeutic drug to combat certain rare diseases caused by gene mutations.For example: lymphangioleiomyomatosis, and facial angiofibroma associated with tuberous sclerosis.
Sirolimus has shown great potential in the fields of anti-tumor, neuroprotection, and anti-aging.
Sirolimus can be produced as a veterinary drug, for example, for heart disease in cats.

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