A Brief Introduction to Diethylstilbestrol
Molecular Formula:C18H20O2
Molecular Weight:268.35
CAS No.:56-53-1
Appearance:White crystalline powder
Regular commercial package: 25kg/drum
What is Diethylstilbestrol?
Diethylstilbestrol (DES) was the world’s first synthetically produced estrogen. As a non-steroidal estrogen, it is a drug or chemical substance with estrogenic activity. It was successfully synthesized in the laboratory by Charles Dodds in 1939 and was widely used in the decades that followed to alleviate menopausal symptoms, prevent miscarriage, and suppress lactation, among other female health conditions. However, in recent years, it has been discovered that the use of DES can cause a series of side effects in humans. Therefore, please weigh the pros and cons before making a decision to use it.
Why choose Highassay?
Highassay provides high-quality, low-impurity Diethylstilbestrol (DES) raw materials. Our DES raw materials are white crystalline powders, soluble in ethanol, ether, chloroform, fatty oils, and dilute alkaline solutions, but practically insoluble in water. As a synthetic hormone, Highassay’s raw materials meet GMP standards and comply with the standards of multiple pharmacopoeias (BP/USP). Choosing our raw materials to produce DES ensures the high quality of the final product.
Highassay adheres to strict quality control (QC) to produce Diethylstilbestrol. Buy Diethylstilbestrol in bulk from us now to get competitive market prices.
Diethylstilbestrol can be used to relieve menopausal symptoms
As women age, their estrogen levels generally decline. Estrogen, a lifelong guardian of women’s health, plays a crucial role not only in maintaining fertility but also in their physiological and psychological well-being. Diethylstilbestrol (DES) can help increase estrogen levels, especially for women who have entered menopause. It can alleviate menopausal symptoms such as hot flashes and insomnia, and also improve skin condition. Furthermore, estrogen is effective against osteoporosis, increasing bone density and reducing the risk of fractures.
Diethylstilbestrol (DES) can be used to treat prostate cancer and breast cancer
Studies show that men with high testosterone levels or abnormal androgen receptor activity have a higher risk of prostate cancer because androgens may promote the growth of prostate cancer cells. Increasing estrogen levels in men can effectively reduce androgen production, thereby inhibiting the growth of prostate cancer cells.
Abnormal levels of natural estrogen (such as long-term high estrogen levels) stimulate breast tissue, increasing the risk of breast cancer. Using high doses of synthetic estrogen to occupy estrogen receptors blocks the natural estrogen’s promotion of cancer cell proliferation, thus inhibiting tumor growth and reproduction.
Whether treating prostate cancer or breast cancer, it is advisable to use DES in conjunction with other anticancer drugs as recommended by a doctor. This can not only reduce the side effects of using DES but also further improve the treatment effect.
Diethylstilbestrol (DES) for dogs
Diethylstilbestrol (DES) can help the growth and development of a dog’s fallopian tubes, mammary glands, and other organs. Besides maintaining a dog’s sexual characteristics, it can also treat urinary incontinence, endometritis, retained placenta, and stillbirth in dogs. However, DES has the same harmful side effects on dogs as it does on humans. It is not recommended that you administer it to your dog without consulting a veterinarian.
Types of Diethylstilbestrol Formulations
White tablets, taken orally. Choose the appropriate tablet type and strength according to your doctor’s advice. Use in stages; not suitable for long-term use.
A clear, slightly yellow to pale yellow oily liquid. Generally administered intramuscularly to supplement the body’s estrogen levels.
Specification of Diethylstilbestrol
- Specification of Diethylstilbestrol
| Tests | Standard |
| Characteristics | White crystalline powder |
| Identification | Positive |
| Related substances | Passes |
| Melting range | About 172 D.C. |
| Loss on drying | 0.5% max |
| Heavy metals | 10ppm max |
| Residue on ignition | 0.10% max |
| Assay | 97.0-101.0% |
| Conclusion | Conforms to USP |
Contact with DES can cause irreversible damage to the uterus, and may also lead to infertility, miscarriage, premature birth, and increase the risk of cancer for both the mother and her offspring.
DES was indeed used to prevent miscarriage in the past, but it is now strictly prohibited because DES is carcinogenic. Other methods of miscarriage prevention are recommended.
In the scientific research field, DES can be used as a laboratory research tool to explore the mechanisms of estrogen and related diseases.
About Diethylstilbestrol（DES）
- Diethylstilbestrol (DES) is used to supplement estrogen levels in women, thereby improving women’s health issues such as atrophic vaginitis, female gonadal hypoplasia, menopausal syndrome, senile vulvar dryness, and vaginitis.
- DES is used to suppress lactation after childbirth. DES tablets, made from DES, inhibit milk production by lowering prolactin levels, thus achieving a lactation-suppressing effect.
- When taken orally, DES is less easily metabolized and inactivated by the liver, exhibiting stronger oral activity than natural estrogens (such as estradiol).
- Regular checkups are necessary during DES use to help detect and address problems promptly. Significant gastrointestinal reactions such as nausea and vomiting are common.
- DES is contraindicated for pregnant and breastfeeding women, as it can harm both the woman and the fetus.
- DES in children: More than a decade after the first pregnant women took diethylstilbestrol, the aftereffects of DES in daughters/sons began to appear, such as a significant increase in the incidence of clear cell adenocarcinoma in girls and impact on the genitals in boys.
